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- TSRM 2023: For Non-Male Factor Infertility, Conventional IVF Performs Similarly to ICSI
TSRM 2023: For Non-Male Factor Infertility, Conventional IVF Performs Similarly to ICSI
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Presented by NUWA Fertility at the 2023 Taiwan Society for Reproductive Medicine (TSRM)
At the 2023 TSRM annual meeting, NUWA Fertility presented a study comparing conventional in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) in couples with non-male factor infertility.
The research found no significant differences between the two fertilization methods across multiple embryo development indicators.
Background: Choosing a Fertilization Method in Non-Male Factor Infertility
In IVF treatment for couples with non-male factor infertility, whether ICSI should be routinely used remains a debated topic.
This study aimed to provide clarity by analyzing sibling oocytes from the same patient cohort, dividing them into two groups—one fertilized using conventional IVF, and the other using ICSI—to compare embryonic development outcomes.
Key Objective: Compare ICSI and IVF outcomes using sibling oocytes in couples without male infertility factors.
Study Results: IVF and ICSI Show Similar Outcomes in Non-Male Factor Cases
For couples without male factor infertility, the study compared outcomes between conventional IVF and ICSI using the same batch of eggs. The indicators assessed included:
- 2PN (Two-Pronuclei) Rate – marker of normal fertilization
- Day 5 Blastocyst Formation Rate
- Total Blastocyst Formation Rate
- Top-Quality Embryo Rate
- Euploidy Rate (based on PGS results)
The findings showed no statistically significant differences across all parameters.
This clearly suggests that routine use of ICSI in non-male factor cases does not provide additional benefit over conventional IVF.
Clinical Significance: Conventional IVF Can Be a Preferred First-Line Approach
The key conclusion of this study is that for patients without male factor infertility, ICSI offers no clear clinical advantage over traditional IVF.
In such cases, conventional IVF—which more closely mimics natural fertilization—may be considered the preferred first-line option. This approach could reduce both treatment costs and unnecessary invasive procedures.
NUWA Fertility is committed to providing individualized treatment strategies based on the latest clinical research.
For patients with non-male factor infertility, we carefully assess each case and engage in open, informed discussions to determine the most suitable and effective fertilization method—ultimately improving IVF outcomes and supporting every couple’s journey toward parenthood.
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