Academic Achievement

A New Option in Sperm Testing: The Potential of Taiwan-Made LensHooke® X1 PRO in Fertility Assessment

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Presented by NUWA Fertility at the 2023 Taiwan Society for Reproductive Medicine (TSRM)

At the 2023 TSRM annual meeting, NUWA Fertility presented a study evaluating the performance of the Taiwan-made LensHooke® X1 PRO, a new computer-assisted semen analysis (CASA) system.
The results showed a high correlation between the X1 PRO and traditional manual microscopic semen analysis, suggesting strong potential for clinical use as a reliable alternative diagnostic tool.

Background: Enhancing the Objectivity and Efficiency of Semen Analysis


Semen analysis is a crucial component of evaluating male fertility.
While traditional manual microscopic analysis is widely accepted and considered accurate, it is subject to operator variability and subjective interpretation.

The emergence of CASA (Computer-Assisted Semen Analysis) systems aims to improve both efficiency and objectivity. This study assessed the reliability of the LensHooke® X1 PRO, comparing its results with those of manual semen analysis.

The emergence of CASA (Computer-Assisted Semen Analysis) systems aims to improve both efficiency and objectivity. This study assessed the reliability of the LensHooke® X1 PRO, comparing its results with those of manual semen analysis.



Methods: Evaluating the Consistency, Sensitivity, and Accuracy of X1 PRO

The research team compared semen parameters measured by the LensHooke® X1 PRO CASA system and manual microscopic semen analysis, assessing: Correlation, Consistency, Sensitivity, Specificity, Overall accuracy.

Key semen parameters such as sperm concentration, motility, and morphology were rigorously analyzed to determine performance alignment between the two methods.

Key semen parameters such as sperm concentration, motility, and morphology were rigorously analyzed to determine performance alignment between the two methods.

Results: High Agreement Between LensHooke® X1 PRO and Manual Analysis

The study found that the LensHooke® X1 PRO showed strong consistency with manual semen analysis across multiple semen quality parameters.

Notably, at specific diagnostic thresholds, the X1 PRO demonstrated high sensitivity, specificity, and accuracy, indicating that it is reliable for identifying abnormal semen samples.

Notably, at specific diagnostic thresholds, the X1 PRO demonstrated high sensitivity, specificity, and accuracy, indicating that it is reliable for identifying abnormal semen samples.


Clinical Implications: X1 PRO as a Promising Alternative for Semen Diagnostics

The study’s findings suggest that the Taiwan-made LensHooke® X1 PRO delivers consistent and reliable results comparable to manual analysis, and performs well under specific clinical conditions.

This indicates strong potential for X1 PRO to serve as a trusted alternative in clinical semen diagnostics, enhancing workflow efficiency and reducing subjectivity in fertility assessments.

The research team emphasized the need for further studies to validate X1 PRO’s full clinical value in the context of male fertility evaluation.

NUWA Fertility remains committed to advancing diagnostic technologies in reproductive medicine.
We continue to evaluate next-generation CASA systems, such as LensHooke® X1 PRO, to provide patients with more accurate, efficient, and comprehensive male fertility assessment services.

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