Academic Achievement

New Frozen Embryo Technology: Laser-Assisted Blastocyst Shrinkage to Improve Pregnancy Rates

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NUWA Fertility presented the latest research at the 2024 Taiwan Society of Reproductive Medicine (TSRM), confirming that for blastocysts of certain sizes, using laser-assisted shrinkage technology before vitrification freezing can significantly enhance the pregnancy potential of subsequent thawed embryo transfers.

Research Background: Why is Laser-Assisted Blastocyst Shrinkage Needed?

Vitrification freezing is an advanced technique for embryo preservation. However, during the freezing process, excessive fluid inside the blastocyst may reduce the efficiency of cryoprotectant exchange and increase the risk of ice crystal formation, which can damage embryo cells. To address this issue, this study aimed to investigate whether reducing the fluid inside the blastocyst through laser-assisted shrinkage could optimize vitrification outcomes and thereby improve subsequent pregnancy rates.

this study aimed to investigate whether reducing the fluid inside the blastocyst through laser-assisted shrinkage could optimize vitrification outcomes and thereby improve subsequent pregnancy rates.

Research Method: Exploring the Effect of Laser Shrinkage on Pregnancy Rates


This study focused on blastocysts undergoing vitrification freezing, examining whether the use of laser-assisted shrinkage before freezing affects clinical pregnancy rates after thawing and transfer. The research team rigorously analyzed relevant data to evaluate the potential benefits of this new technology.

Study Focus: Does Laser-Assisted Shrinkage of Blastocysts Used in Vitrification Affect Clinical Pregnancy Rates After Thawing and Transfer?

Research Results: Laser Shrinkage Significantly Enhances Pregnancy Potential for Blastocysts of Certain Sizes


The results clearly showed that for embryos larger than 150 micrometers (μm), applying laser-assisted shrinkage before vitrification freezing significantly improved the freezing outcome, thereby increasing the pregnancy potential of high-quality blastocysts during thaw cycles. This finding provides important clinical guidance on more effective embryo preservation and selection.

Conclusion and Clinical Significance


This study confirms that laser-assisted blastocyst shrinkage technology can optimize vitrification outcomes under certain conditions and increase the success rate of subsequent embryo implantation. The application of this new technology is expected to bring higher pregnancy chances to more couples seeking IVF treatment. NUWA Fertility will continue to monitor the latest advances in reproductive medicine research and apply promising technologies to clinical practice to provide higher-quality services to patients.

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